Telencephalon?specific <i>Alkbh1</i> conditional knockout mice display hippocampal atrophy and impaired learning

AlkB homolog 1 (ALKBH1) is responsible for the biogenesis of 5-formylcytidine (f5C) on mitochondrial tRNAMet and essential protein synthesis. The brain, especially hippocampus, highly susceptible to dysfunction; hence, maintenance activity strongly required prevent disorders associated with hippocampal malfunction. To study role ALKBH1 in we generated dorsal telencephalon-specific Alkbh1 conditional knockout (cKO) mice inbred C57BL/6 background. These showed reduced respiratory chain complex, atrophy, CA1 pyramidal neuron abnormalities. Furthermore, performances fear-conditioning Morris water maze tests cKO indicated that abnormalities led impaired hippocampus-dependent learning. findings indicate critical roles hippocampus.